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A total of 3 % of Lively substance is excreted in urine as unchanged Energetic material. Tapentadol is Furthermore metabolised to N-desmethyl tapentadol (thirteen %) by CYP2C9 and CYP2C19 and to hydroxy tapentadol (2 %) by CYP2D6, which might be even further metabolised by conjugation. Consequently, Energetic substance metabolism mediated by cytoch